IMPACT OF OMEPRAZOLE ON THE PLASMA-CLEARANCE OF METHOTREXATE

Authors
REID T YUEN A CATOLICO M CARLSON RW
Citation
T. Reid et al., IMPACT OF OMEPRAZOLE ON THE PLASMA-CLEARANCE OF METHOTREXATE, Cancer chemotherapy and pharmacology, 33(1), 1993, pp. 82-84
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy",Oncology
Journal title
Cancer chemotherapy and pharmacology → ACNP
ISSN journal
03445704
Volume
33
Issue
1
Year of publication
1993
Pages
82 - 84
Database
ISI
SICI code
0344-5704(1993)33:1<82:IOOOTP>2.0.ZU;2-3
Abstract
Omeprazole inhibits the gastric hydrogen pump and is an effective trea tment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion- dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic m ethotrexate levels.