A NOTE ON THE COMPLEX METABOLISM OF DANTHRON INFUSED INTO THE RAT

Citation
Rb. Sund et al., A NOTE ON THE COMPLEX METABOLISM OF DANTHRON INFUSED INTO THE RAT, Pharmacology, 47, 1993, pp. 134-137
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
00317012
Volume
47
Year of publication
1993
Supplement
1
Pages
134 - 137
Database
ISI
SICI code
0031-7012(1993)47:<134:ANOTCM>2.0.ZU;2-P
Abstract
Danthron infused intravenously in rats shows a complex dose-dependent pattern of metabolism and excretion. The metabolites, particularly the more polar ones, are in general excreted predominantly in bile, to a lesser extent in urine. They can be separated as metabolite groups acc ording to polarity and molecular size on a Sephadex LH 20 column. The present paper describes a further study within a bile-derived metaboli te group, which proved to be particularly heterogeneous. It contained more than a dozen metabolites, which were conjugates of four different aglycons including the parent danthron. H-1 NMR spectral data for dan thron monosulfate and monoglucuronide are also presented.