SENNOSIDES AND ALOIN DO NOT PROMOTE DIMETHYLHYDRAZINE-INDUCED COLORECTAL TUMORS IN MICE

Authors
SIEGERS CP SIEMERS J BARETTON G
Citation
Cp. Siegers et al., SENNOSIDES AND ALOIN DO NOT PROMOTE DIMETHYLHYDRAZINE-INDUCED COLORECTAL TUMORS IN MICE, Pharmacology, 47, 1993, pp. 205-208
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology → ACNP
ISSN journal
00317012
Volume
47
Year of publication
1993
Supplement
1
Pages
205 - 208
Database
ISI
SICI code
0031-7012(1993)47:<205:SAADNP>2.0.ZU;2-L
Abstract
In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as we ll as parameters of hepato- and nephrotoxicity were observed.