A CONTROLLED COMPARISON OF THE EFFECTS OF PROPRANOLOL, BENZTROPINE, AND PLACEBO ON AKATHISIA - AN INTERIM ANALYSIS

Authors
ADLER LA PESELOW E ROSENTHAL M ANGRIST B
Citation
La. Adler et al., A CONTROLLED COMPARISON OF THE EFFECTS OF PROPRANOLOL, BENZTROPINE, AND PLACEBO ON AKATHISIA - AN INTERIM ANALYSIS, Psychopharmacology bulletin, 29(2), 1993, pp. 283-286
Citations number
10
Categorie Soggetti
Psychiatry,Neurosciences,"Pharmacology & Pharmacy
Journal title
Psychopharmacology bulletin → ACNP
ISSN journal
00485764
Volume
29
Issue
2
Year of publication
1993
Pages
283 - 286
Database
ISI
SICI code
0048-5764(1993)29:2<283:ACCOTE>2.0.ZU;2-X
Abstract
A group of 28 patients was treated to compare the effects on akathisia of the following: propranolol (80 mg/day), benztropine (6 mg/day), or placebo. Both propranolol and benztropine significantly improved akat hisia by Day 3-5 of treatment. Placebo had no significant effects on a kathisia. Three patients developed confusion or forgetfulness by Day 3 of benztropine treatment: these effects cleared upon discontinuation of benztropine.