EFFECT OF SMALL DOSES OF ETHYLENE-GLYCOL MONOMETHYL ETHER ON THE ACETYLCHOLINESTERASE AND DELTA-AMINOLEVULINIC-ACID DEHYDRATASE ACTIVITY INERYTHROCYTES, BLOOD AND BONE-MARROW OF RATS

The effect of small doses of ethylene glycol monomethyl ether (EGMME) on the activity of acetylcholinesterase (ACHE) in erythrocytes and who le blood as well as on the DELTA-aminolevulinic acid dehydratase (ALA- D) in blood and bone marrow was studied in Wistar rats. Significant re duction in the activity of both enzymes was noted three days after ip administration of 200 mg/kg b.w. EGMME whereas seven days later the ac tivity of both enzymes returned to the control levels. Activity of ALA -D in blood appeared to be most sensitive to EGMME, and reacted even t o the lowest dose, which did not significantly alter activity of ACHE or ALA-D in bone marrow. Haematological parameters in all treated grou ps remained unaltered