EFFECTS OF TOPICAL APPLICATION OF UF-021, A NOVEL PROSTAGLANDIN-RELATED COMPOUND, ON AQUEOUS-HUMOR DYNAMICS IN RABBIT

Authors
SAKURAI M ARAIE M OSHIKA T MORI M SHOJI N MASUDA K
Citation
M. Sakurai et al., EFFECTS OF TOPICAL APPLICATION OF UF-021, A NOVEL PROSTAGLANDIN-RELATED COMPOUND, ON AQUEOUS-HUMOR DYNAMICS IN RABBIT, Japanese Journal of Ophthalmology, 37(3), 1993, pp. 252-258
Citations number
31
Categorie Soggetti
Ophthalmology
Journal title
Japanese Journal of Ophthalmology → ACNP
ISSN journal
00215155
Volume
37
Issue
3
Year of publication
1993
Pages
252 - 258
Database
ISI
SICI code
0021-5155(1993)37:3<252:EOTAOU>2.0.ZU;2-E
Abstract
The mechanism underlying the intraocular pressure (IOP) lowering effec t of a novel prostaglandin-related compound, (+)-isopropyl dihydroxy-2 -(3-oxodecyl)-cyclopentyl]hept-5-enoate (UF-021), and the influence of this new hypotensive agent on the permeability of the blood-aqueous b arrier (BAB) were studied in albino rabbits. A single instillation of 0.06% UF-021 significantly lowered the IOP with a peak reduction of 5. 2 mmHg without changing the aqueous flow rate. Uveoscleral outflow and outflow facility to general blood circulation were both increased. Th e BAB permeability evaluated with fluorescein isothiocyanate-labeled r abbit albumin (FITC-RA) showed approximately sixfold increase after a single instillation of 0.06% UF-021, which suggested a drug-induced co mpromise of the rabbit BAB.