We report on 2 patients, one female and one male transsexual; in both,
Type III stress urinary incontinence developed after gender reassignm
ent surgery. Both patients were treated by periurethral injection of g
luteraldehyde cross-linked collagen resulting in a marked symptomatic
improvement in association with a significant rise in abdominal leak p
oint pressures. We believe these are the first reported cases of colla
gen injection being used for urinary incontinence after gender reassig
nment surgery.