THE COMPARATIVE EFFICACY OF BENZOYL PEROXIDE 5-PERCENT ERYTHROMYCIN 3-PERCENT GEL AND ERYTHROMYCIN 4-PERCENT ZINC 1-CENTER-DOT-2-PERCENT SOLUTION IN THE TREATMENT OF ACNE-VULGARIS
A. Chu et al., THE COMPARATIVE EFFICACY OF BENZOYL PEROXIDE 5-PERCENT ERYTHROMYCIN 3-PERCENT GEL AND ERYTHROMYCIN 4-PERCENT ZINC 1-CENTER-DOT-2-PERCENT SOLUTION IN THE TREATMENT OF ACNE-VULGARIS, British journal of dermatology, 136(2), 1997, pp. 235-238
This randomized 10-week study compared the efficacy of benzoyl peroxid
e 5%/erythromycin 3% gel with erythromycin 4%/zinc 1.2% solution in 72
acne vulgaris patients. Physician global evaluations were significant
ly more improved (P less than or equal to 0.05) in the benzoyl peroxid
e 5%/erythromycin 3% gel treatment group compared to erythromycin 4%/z
inc 1.2% solution at week 2 and at each subsequent biweekly clinical v
isit. Inflammatory lesions (papules/pustules) were significantly more
reduced (P less than or equal to 0.005) in the benzoyl peroxide 5%/ery
thromycin 3% gel treatment group than the erythromycin 4%/zinc 1.2% so
lution at weeks 4 and 10. Comedones were significantly more reduced (P
less than or equal to 0.001) in the benzoyl peroxide 5%/erythromycin
3% gel treatment group than in the erythromycin 4%/zinc 1.2% solution
group at weeks 8 and 10. Patient efficacy evaluations significantly (P
less than or equal to 0.001) favoured benzoyl peroxide 5%/erythromyci
n 3% gel to erythromycin 4%/zinc 1.2% solution.