COCAINE AND SEVERAL SIGMA-RECEPTOR LIGANDS INHIBIT DOPAMINE UPTAKE INRAT CAUDATE-PUTAMEN

Authors
IZENWASSER S NEWMAN AH KATZ JL
Citation
S. Izenwasser et al., COCAINE AND SEVERAL SIGMA-RECEPTOR LIGANDS INHIBIT DOPAMINE UPTAKE INRAT CAUDATE-PUTAMEN, European journal of pharmacology, 243(2), 1993, pp. 201-205
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
243
Issue
2
Year of publication
1993
Pages
201 - 205
Database
ISI
SICI code
0014-2999(1993)243:2<201:CASSLI>2.0.ZU;2-Z
Abstract
Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibit ion of dopamine uptake and displacement of the binding of [H-3]WIN 35, 428 (also called CFT), a cocaine analog with high affinity for the dop amine transporter. Since several sigma receptor ligands have been show n to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse.