INTERFERON-OMEGA SUPPRESSES HEPATITIS-B SURFACE-ANTIGEN PRODUCTION INHUMAN HEPATOMA-CELL LINE

Authors
HAJNICKA V FUCHSBERGER N LIPTAKOVA H STANCEK D KONTSEK P
Citation
V. Hajnicka et al., INTERFERON-OMEGA SUPPRESSES HEPATITIS-B SURFACE-ANTIGEN PRODUCTION INHUMAN HEPATOMA-CELL LINE, Acta virologica, 40(4), 1996, pp. 221-222
Citations number
15
Categorie Soggetti
Virology
Journal title
Acta virologica → ACNP
ISSN journal
0001723X
Volume
40
Issue
4
Year of publication
1996
Pages
221 - 222
Database
ISI
SICI code
0001-723X(1996)40:4<221:ISHSPI>2.0.ZU;2-5
Abstract
Biological activities of human interferon (IFN) omega are less well ch aracterized than those of other type I human IFNs. We compared the abi lity of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit th e production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line PLC/PRF/5. The results demonstrated that the capac ity of IFN-omega to suppress the HBsAg synthesis was similar to that o f IFN-alpha 2. The kinetics of the inhibitory effect of IFN-gamma diff ered from those of the two other IFNs.