ENCEPHALOPATHY AND AMNESIA FOLLOWING MEFL OQUINE THERAPY

Benign psychiatric side effects have been frequently associated with m efloquine therapy. On the other hand, severe psychiatric disorders due to mefloquine are rare but must be detected by physicians. Two such c ases are reported. In the first case, excessive curative mefloquine th erapy caused an acute psychotic state which ultimately regress without treatment. The second report concerns a transient memory failure foll owing prophylactic mefloquine treatment. The causative role of this co mpound is being discussed and the importance of a differential diagnos is of neuropsychiatric disorders from toxic or parasitic origin is und erlined Circumstances aggravating such neuropsychiatric side effects a nd actual recommendations concerning the prescription of mefloquine ar e recalled.