DIFFERENCES BETWEEN ORIGINAL STRAINS AND THEIR MOUSE-ADAPTED VARIANTSOF HUMAN (H1) AND AVIAN (H2) INFLUENZA-A VIRUSES IN THE REACTION WITHCROSS-NEUTRALIZING MONOCLONAL-ANTIBODY RECOGNIZING CONFORMATIONAL EPITOPE

Authors
LIPATOV AS GITELMAN AK SMIRNOV YA
Citation
As. Lipatov et al., DIFFERENCES BETWEEN ORIGINAL STRAINS AND THEIR MOUSE-ADAPTED VARIANTSOF HUMAN (H1) AND AVIAN (H2) INFLUENZA-A VIRUSES IN THE REACTION WITHCROSS-NEUTRALIZING MONOCLONAL-ANTIBODY RECOGNIZING CONFORMATIONAL EPITOPE, Acta virologica, 40(4), 1996, pp. 227-230
Citations number
17
Categorie Soggetti
Virology
Journal title
Acta virologica → ACNP
ISSN journal
0001723X
Volume
40
Issue
4
Year of publication
1996
Pages
227 - 230
Database
ISI
SICI code
0001-723X(1996)40:4<227:DBOSAT>2.0.ZU;2-U
Abstract
Human (H1) and avian (H2) influenza A viruses and their mouse-adapted (MA) variants were studied in radioimmunoprecipitation assay (RIPA) an d infectivity neutralization test using a monoclonal antibody (MoAb) d irected against a conserved antigenic epitope in the stem region of th e haemagglutinin (HA) and reacting both with H1 and H2 subtypes of HA Whereas the MA variant of avian influenza A virus differed from the or iginbal strain in RTPA and neutralization tests, no differences were o bserved between the original human strain and its MA variant, as well as between the original H1 and H2 strains.