CELLULAR IMMUNE-RESPONSE TO SIVMAC AND HIV-2 IN MACAQUES - MODEL FOR THE HUMAN HIV-1 INFECTION

Authors
VOSS G HUNSMANN G
Citation
G. Voss et G. Hunsmann, CELLULAR IMMUNE-RESPONSE TO SIVMAC AND HIV-2 IN MACAQUES - MODEL FOR THE HUMAN HIV-1 INFECTION, Journal of acquired immune deficiency syndromes, 6(9), 1993, pp. 969-976
Citations number
72
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Journal of acquired immune deficiency syndromes → ACNP
ISSN journal
08949255
Volume
6
Issue
9
Year of publication
1993
Pages
969 - 976
Database
ISI
SICI code
0894-9255(1993)6:9<969:CITSAH>2.0.ZU;2-U
Abstract
SIV and HIV-2 infection of macaques has become a widely used model to study human HIV infection because the pathogenicity of, as well as the immune responses to, the viruses can be examined conveniently. In par ticular, the cellular immune responses to SIV or HIV-2 have been inves tigated thoroughly. This review summarizes the knowledge about helper and cytotoxic T-cell immunity in macaques, and it discusses the releva nce and applications of this primate animal model for AIDS research.