WOUND-HEALING PROCESS IN THE PORTIO-VAGINALIS-UTERI AFTER CO2-LASER TREATMENT

In order to determine the wound healing process in the portio vaginali s uteri, [H-3]-thymidine incorporation and hydroxyproline concentratio n in the granulation tissue were measured histochemically after CO2-la ser treatment. As a result, the squamous epithelium showed the thymidi ne uptake in extended regions in the first week and in basel cell hype rplastic regions in the second week. The uptake was seen in the reserv e cell hyperplastic regions of the epithelium from the 2nd week. Hydro xyproline concentration peaks mostly appeared within one week after th e laser treatment. After cryosurgery, the peaks mostly appeared after two weeks or more. These results indicated that, the stromas and then the squamous and columnar epithelial cells in tum were regenerated aft er CO2-laser treatment, and that the regeneration occurred earlier aft er laser treatment than after cryosurgery.