Background: This article reports the first known outbreak of Salmonell
a poona infection in a neonatal unit. Three babies had stool cultures
positive for the organism. At the same time, S. poona was the cause of
a nationwide food-borne outbreak associated with contaminated cantelo
upe. To minimize the neonatal outbreak, surveys were performed and con
trol measures were instituted. Methods: Epidemiologic surveillance inc
luded the culture of rectal swabs collected from 48 employees, 18 babi
es, and four family members of the babies. Control measures used inclu
ded the placement in cohorts and isolation of infected babies, strict
adherence to universal precautions, and the restriction of visitation
in the nursery. Results: A total of three babies and one employee in t
he surveillance were found to have Salmonella sp. An additional two ho
spitalized adult patients had S. poona. Of all the people included in
the surveillance, only the three babies were found to have S. poona. T
he hospital employee had S. enteritidis. Conclusions: Timely culture r
esults, rapid cohort placement of infected babies, and strict adherenc
e to universal precautions led to the successful eradication of the or
ganism.