SPECIFIC IGG2 ANTIBODIES TO PSEUDOMONAS-AERUGINOSA LIPID-A AND LIPOPOLYSACCHARIDE ARE EARLY MARKERS OF CHRONIC INFECTION IN PATIENTS WITH CYSTIC-FIBROSIS
G. Kronborg et al., SPECIFIC IGG2 ANTIBODIES TO PSEUDOMONAS-AERUGINOSA LIPID-A AND LIPOPOLYSACCHARIDE ARE EARLY MARKERS OF CHRONIC INFECTION IN PATIENTS WITH CYSTIC-FIBROSIS, Infection, 21(5), 1993, pp. 297-302
The IgG subclass antibody response to the two parts of Pseudomonas aer
uginosa lipopolysaccharide; endotoxic lipid A and the O-polysaccharide
, were investigated in a retrospective longitudinal study involving 16
patients with cystic fibrosis and chronic P. aeruginosa lung infectio
n. The purpose of the study was to see if any of the IgG subclasses of
either specificity could be used as prognostic markers in the develop
ment and subsequent course of the lung disease. IgG2 anti-lipid A, IgG
3 anti-lipid A, and IgG2 anti-polysaccharide showed a significant posi
tive correlation with deteriorating pulmonary function already before
chronic P. aeruginosa lung infection was diagnosed as well as in subse
quent years. The findings suggest antigenic exposure of the patient be
fore chronic infection is detected by routine sputum examinations, and
further support our previous findings of a critical role of the IgG s
ubclass response in modulating the course of inflammatory lung damage
in these patients.