CHOLINERGIC EXCITATION OF SMOOTH-MUSCLE

Authors
SIMS SM JANSSEN LJ
Citation
Sm. Sims et Lj. Janssen, CHOLINERGIC EXCITATION OF SMOOTH-MUSCLE, News in physiological sciences, 8, 1993, pp. 207-212
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
8
Year of publication
1993
Pages
207 - 212
Database
ISI
SICI code
0886-1714(1993)8:<207:CEOS>2.0.ZU;2-E
Abstract
Acetylcholine activates muscarinic receptors on smooth muscle to cause depolarization and contraction. Several mechanisms can contribute to depolarization, including activation of inward cation and Cl- currents , suppression of outward K+ currents, and augmentation of voltage-depe ndent Ca2+ current. Acetylcholine also releases Ca2+ from internal sto res, directly contributing to contraction.