THE STUDY OF COMPLEXATION OF COPPER(II) IONS WITH AMPICILLIN .2. DYNAMICS OF REACTIONS

In the presence of ampicillin copper(II) ions form different coordinat ion compounds. Their formation and the properties of particular specie s were examined by means of UV, Vis and IR spectrometry. The dynamics of complex formation was studied. Firstly, an unstable blue-violet coo rdination compound with an absorption maximum at 590 nm was formed, la ter being transformed into a more stable compound. Hydrolysis of the b eta-lactam group is promoted by copper(II) and/or hydroxide ions and a s a result the-ampicillin ligand (L) is transformed into ampicilloic a cid (L). Consequently, the coordination compounds [CuL]+, CuL2, [CuL3 ]- are changed to [CuL]+, CuL*2 and [CuL3*]-, respectively.