I. Panderi et M. Parissipoulou, DETERMINATION OF CLOPAMIDE-PINDOLOL COMBINATION IN TABLETS BY 4TH-ORDER DERIVATIVE UV SPECTROPHOTOMETRY, International journal of pharmaceutics, 99(2-3), 1993, pp. 327-331
A fourth-derivative spectrophotometric procedure for the simultaneous
determination of clopamide and pindolol in binary mixtures, in tablets
, is described. Calibration graphs are linear (r = 0.9999), the precis
ion (RSD%) better than 2.22 and the percentage relative error (Er%) le
ss than 0.12. No spectral interference from tablet excipients was foun
d. Applications are given for the assay of commercial tablets and cont
ent uniformity test. The procedure proved to be suitable for rapid and
reliable quality control.