GAS-CHROMATOGRAPHIC AND UV DERIVATIVE DETERMINATION OF NITRENDIPINE AND ITS PHOTODEGRADATION PRODUCT

Authors
RAGNO G VERONICO M VETUSCHI C
Citation
G. Ragno et al., GAS-CHROMATOGRAPHIC AND UV DERIVATIVE DETERMINATION OF NITRENDIPINE AND ITS PHOTODEGRADATION PRODUCT, International journal of pharmaceutics, 99(2-3), 1993, pp. 351-355
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
99
Issue
2-3
Year of publication
1993
Pages
351 - 355
Database
ISI
SICI code
0378-5173(1993)99:2-3<351:GAUDDO>2.0.ZU;2-F
Abstract
A rapid and direct analytical UV method, based on third derivative spe ctra, and a gas chromatographic assay, for the simultaneous determinat ion of nitrendipine and its photodegradation product, are proposed. Bo th procedures, showing satisfactory values of accuracy and precision, can be employed to measure the drug and its impurity in pharmaceutical s.