Background. To evaluate the long-term outcome of the sequential vein b
ypass grafting technique, we studied 92 patients with coronary artery
disease undergoing coronary artery bypass grafting in 1984 by one surg
eon and receiving at least one sequential vein bypass graft (total of
170 sequential bypass grafts). Methods. There was one hospital death a
nd 1 patient was lost to follow-up. The remaining 90 patients were fol
lowed up by clinical evaluation, and 80% of the patients underwent cor
onary angiography within 1 year from the end point of the follow-up (J
une 1995), or before recurrence of symptoms or death. Results. All pat
ients except 3 had improvement of their angina class (Canadian Cardiov
ascular Society) at the end of the follow-up. Twelve patients did not
have improvement of their New York Heart Association functional class
postoperatively, but only 1 deteriorated. The mean left ventricular ej
ection fraction remained unchanged at the end of the follow-up period,
and ergometry results were satisfactory during the follow-up period.
The 10-year survival rate was 74%, and the cardiac event-free survival
rate was 72%. Only 37% of the deaths occurring during the follow-up w
ere cardiac-related deaths. In 56 patients with angiographic routine c
ontrol 9 to 10 years postoperatively, 76 of 89 sequential vein grafts
were found patent. Conclusions. It is thought that the optimal long-te
rm results of sequential bypass grafts may be dependent on where the t
erminal anastomosis of the sequence (the end-to-side anastomosis) is p
laced. The technique of sequential grafting with the reversed saphenou
s vein is easier to employ than the single grafting technique, and in
the present study has been demonstrated to have good long-term results
. Furthermore, it allows for a more complete revascularization of the
myocardium, which is particularly important in patients with diffuse c
oronary artery disease. (C) 1997 by The Society of Thoracic Surgeons.