INHIBITION OF BOVINE MONONUCLEAR CELL-PROLIFERATION, INTERLEUKIN-2 SYNTHESIS, PROTEIN-TYROSINE KINASE AND LEUKOTRIENE-B(4) PRODUCTION BY A PROTEIN-TYROSINE KINASE INHIBITOR, GENISTEIN

Authors
ATLURU D GUDAPATY S
Citation
D. Atluru et S. Gudapaty, INHIBITION OF BOVINE MONONUCLEAR CELL-PROLIFERATION, INTERLEUKIN-2 SYNTHESIS, PROTEIN-TYROSINE KINASE AND LEUKOTRIENE-B(4) PRODUCTION BY A PROTEIN-TYROSINE KINASE INHIBITOR, GENISTEIN, Veterinary immunology and immunopathology, 38(1-2), 1993, pp. 113-122
Citations number
30
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
38
Issue
1-2
Year of publication
1993
Pages
113 - 122
Database
ISI
SICI code
0165-2427(1993)38:1-2<113:IOBMCI>2.0.ZU;2-B
Abstract
Genistein, an isoflavanoid compound, a selective inhibitor of protein- tyrosine kinase (PTK), inhibited PHA-stimulated bovine peripheral bloo d mononuclear cell proliferation (PBMC), interleukin-2 (IL-2) producti on, phosphorylation of PTK p56lck. Further, genistein also inhibited l eukotriene B4 production from A-23187 stimulated cultures. Our data su ggest that the PTK plays an important role in the signal transduction of bovine PBMC proliferation.