A FACILE SYNTHESIS OF 7,10-DIDEOXY TAXOL AND 7-EPI-10-DEOXY TAXOL

Authors
CHEN SH WEI JM VYAS DM DOYLE TW FARINA V
Citation
Sh. Chen et al., A FACILE SYNTHESIS OF 7,10-DIDEOXY TAXOL AND 7-EPI-10-DEOXY TAXOL, Tetrahedron letters, 34(43), 1993, pp. 6845-6848
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
43
Year of publication
1993
Pages
6845 - 6848
Database
ISI
SICI code
0040-4039(1993)34:43<6845:AFSO7T>2.0.ZU;2-Z
Abstract
7,10-Dideoxy taxol 2 was prepared from baccatin III in 4 steps via the Barton deoxygenation reaction. Similarly, 7-epi-10-deoxy taxol 3 was prepared in one step from 7 epi taxol in high yield- The key reaction was the tributyltin hydride- mediated direct reduction of the C-10 ace tate.