Rs. Coleman et al., SYNTHESIS OF N-(2-DEOXY-BETA-D-RIBOSYL) 4-THIOMETHYLINDOLE - A PURINESURROGATE FOR INCORPORATION INTO OLIGONUCLEOTIDES, Tetrahedron letters, 34(43), 1993, pp. 6867-6870
Efficient, high-yielding syntheses of S-acetyl-N-(2-deoxy-beta-D-ribos
yl) 4 thiomethylindole (9) and the corresponding 5'-O-trityl-3'-0-phos
phoramidite ester 11 are reported, suitable for direct incorporation i
nto oligodeoxynucleotides by standard solid-phase synthesis techniques
.