SYNTHESIS OF N-(2-DEOXY-BETA-D-RIBOSYL) 4-THIOMETHYLINDOLE - A PURINESURROGATE FOR INCORPORATION INTO OLIGONUCLEOTIDES

Authors
COLEMAN RS DONG Y ARTHUR JC
Citation
Rs. Coleman et al., SYNTHESIS OF N-(2-DEOXY-BETA-D-RIBOSYL) 4-THIOMETHYLINDOLE - A PURINESURROGATE FOR INCORPORATION INTO OLIGONUCLEOTIDES, Tetrahedron letters, 34(43), 1993, pp. 6867-6870
Citations number
42
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
43
Year of publication
1993
Pages
6867 - 6870
Database
ISI
SICI code
0040-4039(1993)34:43<6867:SON4-A>2.0.ZU;2-1
Abstract
Efficient, high-yielding syntheses of S-acetyl-N-(2-deoxy-beta-D-ribos yl) 4 thiomethylindole (9) and the corresponding 5'-O-trityl-3'-0-phos phoramidite ester 11 are reported, suitable for direct incorporation i nto oligodeoxynucleotides by standard solid-phase synthesis techniques .