UROGENITAL MALACOPLAKIA TREATED WITH FLUOROQUINOLONES

We report 2 cases of urogenital malacoplakia and discuss the problems associated with diagnosing and treating this rare disease. In 1 case e xtensive pelvic disease was successfully controlled with ciprofloxacin . In the other case the malacoplakia was localized in the distal urete r and was initially mistaken for urothelial carcinoma. Nephrectomy was performed due to persistent ureteral obstruction and renal dysfunctio n. In the management of urogenital malacoplakia it seems essential tha t urinary tract infections be effectively treated. The new fluoroquino lones appear to be potentially successful in managing this disorder du e to their high uptake of macrophages.