TOPICAL EFFECT OF INTRAVESICAL OXYBUTYNIN

Intravesical oxybutynin was instilled into rat bladders in graded dose s by repeated catheterization to study the local bladder effects of dr ug concentration and incidental urinary infection. On the thirteenth d ay, after 5 doses, bladders were recovered for measurement and histolo gical study. In the highest dose group, systemic absorption from the b ladder caused weight loss and cachexia. However, in no group was there any clear evidence of drug-related mucosal or bladder wall change. In stead, the two high dose groups seemed somehow protected from the comb ined adverse effects of catheterization and infection.