COMBINED ANTIINFLUENZA ACTIVITY OF A PLANT PREPARATION SHS-174 AND AMANTADINE DERIVATIVES

The results of the study on the combined antiviral activity of the SHS -174 preparation (a lyophylized infusion from three higher plants) and three amantadine derivatives (rimantadine, amantadine glucuronide and its derivative) are presented. The antiviral effect of the drugs on t he reproduction of influenza virus strains A/H1N1 and A/H3N2 in vitro was studied. The combined antiviral effect was evaluated on the basis of viral yields and in many cases a synergism was found. The most syne rgistic effect was shown for the combination of SHS-174 with the deriv ative of amantadine glucuronide.