DOES FAMILIAL HYPERTRIGLYCERIDEMIA PREDISPOSE TO NIDDM

Citation
T. Sane et Mr. Taskinen, DOES FAMILIAL HYPERTRIGLYCERIDEMIA PREDISPOSE TO NIDDM, Diabetes care, 16(11), 1993, pp. 1494-1501
Citations number
54
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Journal title
ISSN journal
01495992
Volume
16
Issue
11
Year of publication
1993
Pages
1494 - 1501
Database
ISI
SICI code
0149-5992(1993)16:11<1494:DFHPTN>2.0.ZU;2-1
Abstract
OBJECTIVES- To determine the 1 0-yr incidence of impaired glucose tole rance and NIDDM in families with a clustering of endogenous hypertrigl yceridemia. RESEARCH DESIGN AND METHODS- The prospective population st udy, where the oral glucose tolerance test and the measurement of seru m lipids and lipoproteins were performed at the baseline examination a nd after the 10-yr follow-up, was conducted on 56 subjects (17-60 yr o f age at the baseline). The subjects were from six pedigrees with a cl ustering of endogenous hypertriglyceridemia, and 47 of these subjects attended the follow-up 10 yr later. RESULTS- in the study families, th e prevalence of glucose intolerance and NIDDM increased from 15 to 49% (P < 0.001) and from 2 to 21% (P < 0.001), respectively, over the 10- yr period. When grouped according to the baseline serum triglyceride t ertiles, 76% (P < 0.01) of the family members with highest serum trigl ycerides were glucose intolerant (29% impaired glucose tolerance, 47% NIDDM) at follow-up compared with 20% of those with lowest serum trigl ycerides. In discriminant analysis, including age, body mass index, tr eatment with thiazides and beta-blocking agents, and 2-h serum insulin concentration, the baseline serum triglycerides still remained as an independent predictor of development of impaired glucose tolerance and NIDDM. CONCLUSIONS- Families with a clustering of hypertriglyceridemi a are at increased risk of NIDDM, and in these families elevation of s erum triglycerides serves as a risk marker of glucose intolerance and NIDDM.