TREATMENT OF ACTIVE DISTAL ULCERATIVE-COLITIS WITH IMMUNOGLOBULIN-G ENEMAS

Seven patients with active distal ulcerative colitis were treated with IgG enemas given as a daily bedtime retention enema for two weeks. Ev aluation of effect was assessed by means of sigmoidoscopy with biopsy, measuring acute phase reactants in peripheral blood, and measuring th e faecal protein loss. Clinical signs of active disease were registere d by the patients on a diary chart. Five patients completed the treatm ent period, two patients were withdrawn after 7 and 10 days due to det erioration of disease. Four patients did not register any effect, wher eas one patient improved clinically. In conclusion, rectally administe red IgG did not exert any effect on rectal ulcerative colitis in our s tudy.