INTERSPECIES COMPARISONS OF PLASMA HALF-LIFE OF TRIMETHOPRIM IN RELATION TO BODY-MASS

Authors
PASHOV DA LASHEV LD MATEV IB KANELOV IN
Citation
Da. Pashov et al., INTERSPECIES COMPARISONS OF PLASMA HALF-LIFE OF TRIMETHOPRIM IN RELATION TO BODY-MASS, Journal of veterinary pharmacology and therapeutics, 20(1), 1997, pp. 48-53
Citations number
39
Categorie Soggetti
Pharmacology & Pharmacy","Veterinary Sciences
Journal title
Journal of veterinary pharmacology and therapeutics → ACNP
ISSN journal
01407783
Volume
20
Issue
1
Year of publication
1997
Pages
48 - 53
Database
ISI
SICI code
0140-7783(1997)20:1<48:ICOPHO>2.0.ZU;2-P
Abstract
The relationship between body mass and plasma half-life of trimethopri m was studied in 10 different species of animals and man using publish ed data, Log half-life was positively and significantly correlated to log body mass based on individual measurements in herbivorous animals (n = 23, P < 0.01), in herbivorous animals+pigs (n = 29, P < 0.01), in ungulates (n = 27, P < 0.01), in ruminants (n = 16, P < 0.01) and in non-herbivorous mammals, except pigs (n = 6, P < 0.05), The correlatio n was described by the allometric equations: t(1/2 beta) = 27 W-0.26 i n herbivorous animals and t(1/2 beta) = 125 W-0.32 in non-herbivorous animals except pigs.