THE EXCRETION OF URINARY GLYCOSAMINOGLYCANS BY FLUOROTIC RATS

This study describes differences in excretion of sulphated glycoprotei ns, including glycosaminoglycans and possibly Tam-Horsfall like protei ns, in the urine of fluorotic and control rats. Changes in molecular s ize of protein and covalently bound radiosulphate profiles together wi th differences in Alcian blue and Ponceau S staining of the electropho retically separated molecular size fractions were evident in fluorotic urines. The findings highlight changes in connective tissues in fluor osis which manifest themselves as urinary metabolites.