EVALUATION OF THE ANTINEOPLASTIC ACTIVITIES OF THE RIMINOPHENAZINE AGENTS CLOFAZIMINE AND B669 IN TUMOR-BEARING RATS AND MICE

Authors
VANRENSBURG CEJ DURANDT C GARLINSKI PJ OSULLIVAN JF
Citation
Cej. Vanrensburg et al., EVALUATION OF THE ANTINEOPLASTIC ACTIVITIES OF THE RIMINOPHENAZINE AGENTS CLOFAZIMINE AND B669 IN TUMOR-BEARING RATS AND MICE, International journal of oncology, 3(5), 1993, pp. 1011-1013
Citations number
9
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
3
Issue
5
Year of publication
1993
Pages
1011 - 1013
Database
ISI
SICI code
1019-6439(1993)3:5<1011:EOTAAO>2.0.ZU;2-L
Abstract
The riminophenazine agents clofazimine and its analogue B669 displayed anti-tumor activity at 30 mg/kg/day in benzo[a]pyrene (BP) induced sa rcomas of mice as well as dimethylbenz-anthracene (DMBA)-induced rat m ammary tumors. No hematological toxicity of these drugs at doses up to 60 mg/kg/day for one month was observed. This is the first study to d ocument in vivo anti-neoplastic activities of clofazimine and B669.