THE PRESENCE OF MYOFIBROBLASTS IN THE DERMIS OF PATIENTS WITH DUPUYTREN CONTRACTURE - A POSSIBLE SOURCE FOR RECURRENCE

Citation
Bg. Mccann et al., THE PRESENCE OF MYOFIBROBLASTS IN THE DERMIS OF PATIENTS WITH DUPUYTREN CONTRACTURE - A POSSIBLE SOURCE FOR RECURRENCE, Journal of hand surgery. British volume, 18B(5), 1993, pp. 656-661
Citations number
NO
Categorie Soggetti
Orthopedics,Surgery
ISSN journal
02667681
Volume
18B
Issue
5
Year of publication
1993
Pages
656 - 661
Database
ISI
SICI code
0266-7681(1993)18B:5<656:TPOMIT>2.0.ZU;2-3
Abstract
Samples of skin and underlying cord obtained at dermofasciectomy for D upuytren's contracture have been examined for the presence of smooth m uscle alpha-actin (SM alpha-actin), a marker for myofibroblasts. 15 of the 20 samples stained positively for SM alpha-actin corresponding wi th areas of hypercellular Dupuytren's tissue. In 12 of these 15 sample s SM alpha-actin-positive hypercellular Dupuytren's tissue extended in to the dermis, in three cases reaching the epidermis. In eight samples , diffusely distributed cells positive for SM alpha-actin and resembli ng fibroblasts were seen in the dermis. These cells appeared to be sep arate from the Dupuytren's foci. The presence of hypercellular foci an d isolated fibroblasts positive for SM alpha-actin within the dermis m ay explain the high recurrence rate of Dupuytren's disease after fasci ectomy.