PERITONEAL-DIALYSIS FOR THE REMOVAL OF PROTEIN-BOUND MARKERS OF HEPATIC INSUFFICIENCY

The addition of human serum albumin (HSA) to peritoneal dialysate incr eases the clearance of bilirubin in rats suffering from obstructive ja undice. The acceptor properties of the fluid can be enhanced by using HSA that does not contain standard stabilizing additives and has been purified by further adsorption on activated carbon. Bilirubin-containi ng dialysate fluid, as well as the ascitic fluid of cirrhotic patients , can be regenerated by a combination of membrane ultrafiltration and carbon adsorption. These observations suggest a potentially useful sch eme for continuous, regenerative peritoneal dialysis in the treatment of hepatic insufficiency.