PANCREATIC PENETRATION OF OFLOXACIN - PIL OT-STUDY

The use of antibiotics in patients with necrotizing pancreatitis is in dicated since bacterial complications are the most common cause of dea th in this condition. Ofloxacin was studied in six patients regarding its permeation into pancreatic juice and bile and into pancreatic tiss ue in cases of chronic pancreatitis and pancreatic carcinoma. The peak concentrations in pancreatic juice (3.7 mg/l) and bile (12.9 mg/1) we re found 20 minutes after i.v. administration of 3 mg/kg ofloxacin, th ese are 79 and 275% of the corresponding serum level, respectively. Pa ncreatic tissue concentrations varied between 54 and 333% of serum val ues in relation to the removal time of specimens and to the stage of i nflammation. After three days and five days of ofloxacin treatment wit h doses of 2 x 200 mg daily even in pancreatic necroses concentrations were detected between 0.8 and 3.7 mg/kg wet weight. This suggests tha t in all pancreatic compartments analyzed, sufficient antibacterial of loxacin levels above the MIC of relevant germs were found. Therefore, from a pharmacokinetic point of view, ofloxacin could be a potentially effective drug in prophylaxis and therapy of bacterial infections of the pancreas.