H. Kayser et al., NEW AMINO SUGAR ANALOGS ARE INCORPORATED AT DIFFERENT RATES INTO GLYCOPROTEINS OF MOUSE ORGANS, Experientia, 49(10), 1993, pp. 885-887
Different radiolabelled N-acyl-derivatives of D-glucosamine were synth
esized using D-glucosamine and the respective carbonic acid anhydride.
Metabolism of these sugar analogues could be shown in vitro as well a
s in vivo. After the intraperitoneal administration of these radiolabe
lled N-acyl-D-glucosamines to mice, their rate of incorporation into g
lycoproteins of different organs was found to increase markedly with t
he length of the N-acyl side chain. Highest incorporation was measured
in the whole intestine using N-pentanoyl-D-glucosamine as label.