NEW AMINO SUGAR ANALOGS ARE INCORPORATED AT DIFFERENT RATES INTO GLYCOPROTEINS OF MOUSE ORGANS

Different radiolabelled N-acyl-derivatives of D-glucosamine were synth esized using D-glucosamine and the respective carbonic acid anhydride. Metabolism of these sugar analogues could be shown in vitro as well a s in vivo. After the intraperitoneal administration of these radiolabe lled N-acyl-D-glucosamines to mice, their rate of incorporation into g lycoproteins of different organs was found to increase markedly with t he length of the N-acyl side chain. Highest incorporation was measured in the whole intestine using N-pentanoyl-D-glucosamine as label.