IMPLICATION OF C-5, C-6 UNSATURATION AS A KEY STRUCTURAL FACTOR IN STEROIDAL ALKALOID-INDUCED MAMMALIAN TERATOGENESIS

Authors
GAFFIELD W KEELER RF
Citation
W. Gaffield et Rf. Keeler, IMPLICATION OF C-5, C-6 UNSATURATION AS A KEY STRUCTURAL FACTOR IN STEROIDAL ALKALOID-INDUCED MAMMALIAN TERATOGENESIS, Experientia, 49(10), 1993, pp. 922-924
Citations number
14
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
49
Issue
10
Year of publication
1993
Pages
922 - 924
Database
ISI
SICI code
0014-4754(1993)49:10<922:IOCCUA>2.0.ZU;2-L
Abstract
Hamster teratogenicity induced upon oral administration of steroidal a lkaloids (solanidanes, spirosolanes and jervanes) appears to relate ve ry closely to the presence or absence of C-5, C-6 unsaturation in the alkaloid, which may be more important than molecular configuration at C-22 and placement of the nitrogen atom with regard to the plane of th e steroid.