The modern neurodiagnostic techniques of MR imaging, CT scanning and a
ngiography provide valuable morphological information that, although h
ighly sensitive to tumour localisation, still lacks comparable specifi
city as to the exact histological nature of those lesions demonstrated
. Biopsy remains necessary. To patients with potentially inoperable le
sions or lesions best treated by chemotherapy or irradiation, modern t
echniques of neurosurgery now offer the option of precise stereotactic
biopsy through small twist-drill burr holes as opposed to open biopsy
. The interrelationships between MR, CT, angiography and stereotactic
biopsy and their respective roles in the establishment of a definitive
diagnosis are discussed.