Re. Jorge et al., DEPRESSION AND ANXIETY FOLLOWING TRAUMATIC BRAIN INJURY, The Journal of neuropsychiatry and clinical neurosciences, 5(4), 1993, pp. 369-374
The frequency, course, and clinical correlates Of generalized anxiety
disorder (GAD) and its relationship to major depression were examined
in 66 patients with traumatic brain injury (TBI). Of 66 TBI patients,
7 (11%) had both GAD and major depression; 10 (15%) had major depressi
on without GAD. Median duration was 1.5 months for nonanxious depressi
ons, 7.5 months for anxious depressions, and 1.5 months for concurrent
GAD. Anxious depressions were also associated with right hemisphere l
esions, whereas major depressions alone were associated with left ante
rior lesions. These findings suggest that anxious major depression and
major depression following TBI may be two different disorders with di
fferent underlying etiological mechanisms and perhaps differential res
ponse to treatment.