R. Migliorelli et al., SPECT FINDINGS IN PATIENTS WITH PRIMARY MANIA, The Journal of neuropsychiatry and clinical neurosciences, 5(4), 1993, pp. 379-383
Five patients with a manic episode and 7 age-comparable control subjec
ts were studied with single-photon emission computed tomography and [T
c-99m]d,l-hexamethylpropyleneamine oxime. Manic patients showed signif
icantly lower blood flow in the basal portion of the right temporal lo
be compared with normal control subjects. Moreover, manic patients sho
wed a left-right asymmetry (a significantly lower perfusion in the rig
ht versus left temporal basal cortex), as well as a dorsal-ventral asy
mmetry (a significantly lower perfusion in the right temporal basal ve
rsus dorsal cortex). These findings suggest that the right basotempora
l cortex may play an important role in the production of primary mania
.