In this study, we compare regional cerebral blood flow (rCBF) while Fr
ench monolingual subjects listen to continuous speech in an unknown la
nguage, to lists of French words, or to meaningful and distorted stori
es in French. Our results show that, in addition to regions devoted to
single-word comprehension, processing of meaningful stories activates
the left middle temporal gyrus, the left and right temporal poles, an
d a superior prefrontal area in the left frontal lobe. Among these reg
ions, only the temporal poles remain activated whenever sentences with
acceptable syntax and prosody are presented.