Objective: To determine the frequency and etiology of psychiatric comp
lications in patients with Fabry's disease. Method-Retrospective analy
sis and review of the records of thirty-three patients with confirmed
Fabry's disease. Results: Six patients (18%) developed psychiatric dis
orders. Five patients suffered depression and two of these patients co
mmitted suicide. One patient developed an acute confusional episode wi
th subsequent development of behavioral changes as a complication of c
erebrovascular disease. Conclusions: Psychiatric disorders, most commo
nly depression, complicate Fabry's disease and contribute to the morbi
dity and mortality of this disease.