PSYCHIATRIC-DISORDERS IN PATIENTS WITH FABRYS-DISEASE

Objective: To determine the frequency and etiology of psychiatric comp lications in patients with Fabry's disease. Method-Retrospective analy sis and review of the records of thirty-three patients with confirmed Fabry's disease. Results: Six patients (18%) developed psychiatric dis orders. Five patients suffered depression and two of these patients co mmitted suicide. One patient developed an acute confusional episode wi th subsequent development of behavioral changes as a complication of c erebrovascular disease. Conclusions: Psychiatric disorders, most commo nly depression, complicate Fabry's disease and contribute to the morbi dity and mortality of this disease.