Devices in current use for adsorptive plasma treatment have, in many c
ases, been adapted from other types of separation processes. Minimizin
g system volume and quantity of ligand per mass transferred are propos
ed as appropriate design goals for an adsorptive plasma treatment syst
em. The process consists of two operations: cell/plasma separation and
solute adsorption/desorption. An example of an optimally designed mem
brane cell separator is presented which adds a negligibly small volume
to the system. By overcoming mass transfer limitations, both volume a
nd ligand quantity associated with the sorbent device can be minimized
. Combining both of the above operations in a single device is also fe
asible. Examples are discussed of optimally designed sorbent devices a
nd devices which combine cell separation/solute adsorption.