Me. Meyer et Jm. Shults, DOPAMINE D-1 RECEPTOR FAMILY AGONISTS, SKANDF38393, SKANDF77434, AND SKANDF82958, DIFFERENTIALLY AFFECT LOCOMOTOR ACTIVITIES IN RATS, Pharmacology, biochemistry and behavior, 46(2), 1993, pp. 269-274
Dopamine D-1 receptor family agonists, 2,3,4,5,-tetrahydro-7,8-dihydro
xy- 1phenyl-1H-3-benzazepine (SKandF38393), tetrahydro-7,8-dihydroxy-1
-phenyl-1H-3-benzazepine (SKandF77434), and tetrahydro-7,8-dihydroxy-1
-phenyl-1H-3-benzazepine (SK&F82958), were compared for their behavior
al effects on horizontal movement time, rearing time, stereotypy time,
and thigmotaxis time. All agonists resulted in biphasic effects with
attenuation followed by potentiation (0.01-10.0 mg/kg, SC). While SKan
dF38393 did not potentiate horizontal movement and rearing times, and
had minor effects on thigmotaxis, SKandF77434 and SKandF82958 potentia
ted horizontal movement and rearing behaviors and attenuated thigmotax
is. The results were discussed in terms of the binding characteristics
and current receptor theory.