ALTERING SEX-RATIOS - THE GAMES MICROBES PLAY

The male gametes of most organisms lack cytoplasm. Consequently, most cytoplasmic genetic elements are maternally inherited: they cannot be transmitted patrilinnearly. The evolutionary interests of cytoplasmic elements therefore lie in transmission through the female. These eleme nts may thus be in evolutionary conflict with nuclear genes which are transmitted by both sexes. This conflict is manifested in observations of cytoplasmically induced biased sex-ratios. Some cytoplasmic genes avoid this fate by biasing the primary sex ratio towards females, or b y inducing parthenogenesis. Others kill male hosts, and either achieve transmission via dispersal, or benefit their clonal relatives in the dead male's female siblings. Still others cause the failure of zygotes resulting from pairings between males carrying specific microbes and females lacking them, causing an increase in the microbes through the sterilisation of non-bearing females. Many, but not all, of these 'ult ra-selfish' microbes are closely related. Investigations of the signif icance of their phylogenetic affinities, or lack of them, their adapta bility in terms of the methods by which they avoid, or ameliorate, the adverse effects of being in male hosts, and their importance as selec tive agents in the evolution of invertebrate sex determination systems , provide fertile spheres for future research.