CHEMOENZYMATIC SYNTHESIS OF (S)-(-)-FRONTALIN USING BACTERIAL EPOXIDEHYDROLASES

Authors
KROUTIL W OSPRIAN I MISCHITZ M FABER K
Citation
W. Kroutil et al., CHEMOENZYMATIC SYNTHESIS OF (S)-(-)-FRONTALIN USING BACTERIAL EPOXIDEHYDROLASES, Synthesis, (2), 1997, pp. 156
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
2
Year of publication
1997
Database
ISI
SICI code
0039-7881(1997):2<156:CSO(UB>2.0.ZU;2-F
Abstract
The pheromone (S)-(-)-frontalin (1) was synthesized in five steps in 9 4 % ee via a chemoenzymatic route. In the key step, 2-methyl-2-(pent-4 -enyl)oxirane [(+/-)-7a] was resolved employing lyophilized cells of R hodococcus equi IFO 3730 (E = 39).