HIV-1 REVERSE-TRANSCRIPTASE INHIBITORY PRINCIPLES FROM CHAMAESYCE HYSSOPIFOLIA

In the course of our studies on the development of anti-acquired immun odeficiency syndrome (AIDS) agents, we isolated corilagin, quercetin 3 -O-beta-D-glucopyranoside and 1,3,4,6-tetra-O-galloyl-beta-D-glucopyra nos from Chamaesyce hyssopifolia, as the main inhibitory substances ag ainst human immunodeficiency virus (HIV) reverse transcriptase, an enz yme essential for the proliferation of HIV. The IC50 of these substanc es were 20, 50 and 86 mu M, respectively, their modes of inhibition be ing non-competitive with respect to the substrate. (C) 1997 by John Wi ley & Sons, Ltd.