AN ALKALOIDAL EXTRACT (ALKS1) FROM TROPHIS-RACEMOSA LOWERS INTRAOCULAR-PRESSURE IN DOGS

Authors
GOSSELLWILLIAMS MD WEST ME SIMON O
Citation
Md. Gossellwilliams et al., AN ALKALOIDAL EXTRACT (ALKS1) FROM TROPHIS-RACEMOSA LOWERS INTRAOCULAR-PRESSURE IN DOGS, PTR. Phytotherapy research, 11(1), 1997, pp. 57-58
Citations number
10
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
11
Issue
1
Year of publication
1997
Pages
57 - 58
Database
ISI
SICI code
0951-418X(1997)11:1<57:AAE(FT>2.0.ZU;2-T
Abstract
A 1.0% solution of ALKS1, an alkaloidal extract obtained from Trophis racemosa, produced a significant fall in intraocular pressure in the d og's eye (p<0.001). The fall was antagonized by atropine (p<0.0025), s uggesting ALKS1 is acting through a muscarinic mode of action. Further purifcation of the extract is required to determine the actual compou nd producing this effect on the eye. (C) 1997 by John Wiley & Sons, Lt d.