ANTIINFLAMMATORY ACTIONS OF EUPHORBIA SPLENDENS EXTRACT

Petroleum ether extract of the aerial parts of plant Euphorbia splende ns (PEE) was screened for antiinflammatory activity using carrageenan induced oedema test in rats and mice as an acute and adjuvant arthriti s as chronic models. Oral administration of PEE caused significant inh ibition of oedema in these tests and produced inhibition of leucocyte migration and exudate volume in the affected tissues. The oral LD(50) in both rats and mice was approximately 1250 mg/kg. (C) 1997 by John W iley & Sons, Ltd.