ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) ACTIVITY OF ACHYROCLINE FLACCIDA WEIN DC AND GAMOCHAETA-SIMPLICICAULIS AQUEOUS EXTRACTS

Authors
SALOMON H PAMPURO S CAVALLARO L GARCIA G COUSSIO J CAMPOS R
Citation
H. Salomon et al., ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) ACTIVITY OF ACHYROCLINE FLACCIDA WEIN DC AND GAMOCHAETA-SIMPLICICAULIS AQUEOUS EXTRACTS, PTR. Phytotherapy research, 11(1), 1997, pp. 82-83
Citations number
7
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
11
Issue
1
Year of publication
1997
Pages
82 - 83
Database
ISI
SICI code
0951-418X(1997)11:1<82:AT(AOA>2.0.ZU;2-Z
Abstract
The anti-human immunodeficiency virus type-1 (HIV-1) activity of two S outh American plant extracts was studied in vitro. The concentrations of aqueous extracts of Achyrocline flaccida Wein DC (AF) and Gamochaet a simplicicaulis (GS) that inhibit 50% of viral production were 3 and 5 mu g/mL respectively. The concentrations that inhibit cellular growt h were 400 and 600 mu g/mL. Non-virucidal activity was detected. The r esults indicate that the potent anti-HIV-1 activities of both AF and G S extracts might occur at an early step of viral replication on infect ed lymphocytes of primary origin. (C) 1997 by John Wiley & Sons, Ltd.